Rodrigo Pavani
Senior Medical Director Clinical Research Regeneron Pharmaceuticals
Seminars
Thursday 23rd July 2026
Roundtable Discussion: Redefining Clinical Success Metrics to Ensure Meaningful Functional Recovery in Peripheral Neuropathies Disease
2:00 pm
- Evaluating score-based severity reduction, such as reducing a scale from 1 to 0.5, and questioning whether statistical improvement translates into tangible muscle function recovery like improved grip strength, brushing teeth, or walking stability
- Comparing existing neurological assessment tools (e.g., grip strength, MRC scores and other scales), analysing their variability and lack of a clear gold standard to determine which tools best capture meaningful neuromuscular improvement in Phase III trials
- Defining what “good enough” improvement means, acknowledging that partial improvement may not reflect meaningful daily function restoration to align trial endpoints with patient-relevant outcomes rather than abstract metrics
Thursday 23rd July 2026
Roundtable Discussion: Navigating Patient Recruitment & Competitive Saturation in Rare Autoimmune Diseases
11:30 am
- Managing patient recruitment in oversaturated MG landscapes
- Discuss washout challenges and competitive trial overlap to proactively mitigate enrolment risk and ethical challenges
- Identifying strategies to differentiate in competitive FcRn and complement markets to protect trial feasibility in rare disease populations
